During the final years of her art history studies in 1971, Blotkamp learned computer programming as part of a course in Sonology at the Institute of Sonology in Utrecht, a globally recognized institution known for its groundbreaking work in computer-generated music and art. This was the same institution where her close friend, artist Peter Struycken, had begun working with computers in 1968. She soon started creating visual works through computer technology, developing a distinctive artistic approach.
Initially, her colorful, graphic patterns existed solely as software: infinite moving images on a screen, ephemeral and continuously overwritten by the next. By around 1990, however, her computer-generated images began to take on a more permanent form. Under the name Decomachine, she experimented with various applied art forms, such as textile and ceramic printing, as well as creating works on stretched fabric.